Join for Exclusive Member Savings!
Join for Exclusive Member Savings!
American Cruise Line cruise deals open the door to explore American's beautiful and iconic Rivers. American Cruise Line offers cruises on the Mississippi River, the Hudson River and the Columbia and Snake Rivers. Immerse yourself in the southern history and culture of the Mississippi from St. Paul to New Orleans. The stunning views and historical sites of the Hudson River are highlighted on a Hudson River Cruise. The Columbia & Snake river lets you explore the Pacific Northwest. Book now and get the best deals on your next American Cruise Line cruise vacation.
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American Pride
Portland/Oregon to Clarkston
Apr 27, 2025 - Nov 9, 2026
Fr $4,485
COLUMBIA & SNAKE RIVER CRUISE
American Pride
Clarkston to Portland/Oregon
May 4, 2025 - Nov 2, 2026
Fr $4,787
COLUMBIA & SNAKE RIVER CRUISE
American West
Clarkston to Portland/Oregon
May 11 - Oct 12, 2025
Fr $4,876
American West
Clarkston to Portland/Oregon
May 11, 2025 - Jul 20, 2026
Fr $4,876
COLUMBIA & SNAKE RIVER CRUISE
American Song
Clarkston to Portland/Oregon
May 6, 2025 - Nov 4, 2026
Fr $5,559
COLUMBIA & SNAKE RIVER CRUISE
American Harmony
Clarkston to Portland/Oregon
May 2, 2025 - Oct 17, 2026
Fr $6,054
American Glory
Albany to New York City
Oct 7 & 21, 2025
Fr $6,614
Fall Foliage Cruise
American Glory
New York City to Albany
Sep 30 & Oct 14, 2025
Fr $6,861
Fall Foliage Cruise
American Glory
New York City to Albany
Oct 5 & 19, 2026
Fr $7,356
American Glory
Albany to New York City
Oct 12 & 26, 2026
Fr $7,356
Mississippi River Cruise
American Heritage
Roundtrip New Orleans
Apr 28, 2025 - May 28, 2026
Fr $3,881
Mississippi River Cruise
American Splendor
New Orleans to Memphis
May 6, 2025 - Jun 3, 2026
Fr $4,253
Mississippi River Cruise
American Splendor
Memphis to New Orleans
Apr 29, 2025 - Nov 11, 2026
Fr $4,866
Mississippi River Cruise
American Serenade
Memphis to New Orleans
Apr 26, 2025 - Oct 23, 2026
Fr $5,139
Mississippi River Cruise
American Symphony
New Orleans to Memphis
Mar 4 - Dec 24, 2026
Fr $5,223
American Glory
New York City to Boston
May 5, 2025 & May 22, 2027
Fr $5,693
American Glory
Roundtrip Boston
May 12, 2025 - Sep 21, 2026
Fr $5,693
American Independence
New York City to Boston
May 26, 2025
Fr $5,782
American Eagle
New York City to Boston
Jul 29, 2025
Fr $5,911
American Legend
Roundtrip Boston
Jun 13 - Sep 19, 2025
Fr $6,965
American Glory
Boston to New York City
Sep 28, 2026
Fr $7,000
American Pioneer
New York City to Boston
Apr 16 & 30, 2026
Fr $7,703
American Patriot
Roundtrip Boston
Jun 7 - Aug 26, 2026
Fr $10,564
American Eagle
Amelia Island to Charleston/South Carolina
May 5, 2025 - Apr 30, 2026
Fr $4,980
American Independence
Roundtrip Baltimore
May 3 - 17, 2025
Fr $5,807
American Liberty
Charleston/South Carolina to Amelia Island
May 3, 2025 - May 16, 2026
Fr $6,465
American Eagle
Amelia Island to Washington, D.C.
May 19, 2025 & May 13, 2026
Fr $10,480
American Constellation
Roundtrip Juneau
May 25, 2025 - Sep 7, 2026
Fr $6,336
American Constitution
Roundtrip Juneau
Jul 7, 2025 - Aug 10, 2026
Fr $6,440
American Constitution
Roundtrip Juneau
Jun 7, 2025 - Aug 27, 2026
Fr $8,876
American Constellation
Seattle to Juneau
May 12, 2025 & May 11, 2026
Fr $11,613
American Constellation
Juneau to Seattle
Sep 15, 2026
Fr $10,514
American Constitution
Juneau to Seattle
Sep 7, 2025 & Sep 6, 2026
Fr $10,514
American Constellation
Fairbanks to Juneau
Jul 16 & Aug 26, 2025
Fr $13,959
Upper Mississippi River Cruise
American Melody
Saint Louis to Saint Paul
Jul 18, 2025 - Oct 10, 2026
Fr $5,490
Upper Mississippi River Cruise
American Serenade
Saint Louis to Saint Paul
Jul 11, 2025 - Aug 8, 2026
Fr $5,490
Upper Mississippi River Cruise
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Saint Louis to Pittsburgh
Jun 20, 2025 - Aug 1, 2026
Fr $10,638
American Constitution
Roundtrip Seattle
Apr 26, 2025 - Oct 18, 2026
Fr $5,049
American Spirit
Roundtrip Seattle
May 10, 2025 - Sep 19, 2026
Fr $5,049
American Constellation
Roundtrip Seattle
Apr 28, 2025 - Oct 20, 2026
Fr $5,049
All offers are based on select sailings and categories and are subject to availability at time of booking. All rates are per person based on double occupancy.
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